Ng, the average optimisms were being 0.03, 0.03 and 0.01, respectively. Conclusions: A hemoglobin <10.0 g

Ng, the average optimisms were 0.03, 0.03 and 0.01, respectively. Conclusions: A hemoglobin < 10.0 g/dL, platelet count < 10.0x104 / L and fibrinogen < 200 mg/dL at 24 hours after injury were associated with mortality. The impact of correction of these values with blood products warrants further validation.Critical Care 2016, Volume 20 SupplPage 54 ofReferences 1) Spahn DR, Bouillon B, Cerny V, et al: Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care 2013;17:R76. 2) Morel N, Delaunay F, Dubuisson V: Management of bleeding following major trauma: is a target haemoglobin of 7 to 9 g/dl high enough? Crit Care. 2013;17:442.P119 Trauma-induced coagulopathy - prothrombin complex concentrate vs fresh frozen plasma O. Tarabrin, S. Shcherbakow, D. Gavrychenko, G. Mazurenko, V. Ivanova, O. Chystikov Odessa National Medical University, Odessa, Ukraine Critical Care 2016, 20(Suppl 2):P119 Introductions: The mortality in the in patients with traumatic injuries in a case of bleeding is the most frequent cause of preventable death after severe injury. Methods: The study involved 91 patients who entered the Odessa Regional Hospital with traumatic injuries: concomitant skeletal trauma, fractures of femur and humerus. Patients were divided into 2 groups: 1st group (n = 46) as a treatment was received PCC in a dose of 1 ml/ kg (25 IU/kg) and TXA in a loading dose of 1 g during 10 minutes followed by an infusion of 1 g during 8 hours at time of admission to the intensive care unit (ICU); 2nd group (n = 45) received FFP in a dose of 15 ml/kg and TXA in a loading dose of 1 g during 10 minutes followed by an infusion of 1 g during 8 hours. Evaluation of the functional state of the hemostasis system was carried out using lowfrequency piezoelectric thromboelastography (LPTEG) on admission to hospital and 24 hours after the patient's admission to the ICU. Results: According to LPTEG indicators traumatic injuries patients has a statistically significant abnormalities in all parts of hemostatic system: platelet aggregation - Intensity of contact coagulation (ICC), the PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/18111632 coagulation – Intensity of coagulation travel (ICD), clot greatest density (MA) and fibrinolytic action – Index of ROCK-IN-2 retraction and clot lysis (IRCL). ICC in individuals with traumatic accidents was minimized by 29.fifty nine , ICD was considerably less than usual at 37.59 , MA was decreased by 74.seventy one , which showed coagulopathy, IRCL was ninety,seventy eight above the norm, which stands expressed hyperfibrinolysis. Sufferers of 1st team in accordance to LPTEG experienced PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/22316373 sizeable alterations in all areas of coagulation 24 hours following the intense treatment. Indicators of platelet hemostasis characterized by persistence of hypoagregation: ICC was minimized by 24.71 , compared to the norm; parameters of coagulation and fibrinolysis have trustworthy craze towards ordinary and reducing the exercise of fibrinolysis index reaches ordinary reference values. Patients of 2nd team have hypoagregation and hypocoagulation condition with decreased active of fibrinolysis: ICC was reduced by 24.seventy two , ICD lowered by twenty.seventy six , MA was diminished by 23.54 , IRCL was within the usual vary. Clinically, sufferers of your 1st team had cutting down the amount of blood transfusions versus the 2nd team. Conclusions: Individuals with trauma-induced coagulopathy have violation in all components of hemostatic system. The use of prothrombin elaborate concentrate and tranexamic acid can cut down the severity of pathological changes within the hemostasis in pat.